Our interests include inpatient glucose management, type 2 diabetes mellitus and diabetic foot ulcers. Research Areas: Raynaud's phenomenon, rheumatology, scleroderma, autoimmune diseases, systemic sclerosis, ischemic ulcers. We also study the development of quantitative measures of immune memory to aid in donor selection and individualization of immunosuppression. Research Areas: granulomatosis with polyangiitis, kidney diseases, vasculitis, kidney transplants, Glomerulonephritis, nephrology. The Elizabeth Wagner Lab conducts research on several topics within the field of pulmonary medicine. The current work involves mouse and human studies to define how enterotoxigenic Bacteroides fragilis, pks+ Escherichia coli, Fusobacterium nucleatum, biofilms and the colonic microbiota induce chronic colonic inflammation and colon cancer. The laborator… Major projects in the Gao Lab include immunogenetic analysis of human response to allergen, identification of candidate genes for specific immune responsiveness to cockroach allergen, and epigenetics of food allergy (FA). Dr. Sperati’s group focuses on complement mediated kidney disorders, glomerular disease, and renal arterial disease secondary to fibromuscular dysplasia. The laboratory identified CaMKII as an important pro-arrhythmic and pro-cardiomyopathic signal, and its studies have provided proof of concept evidence motivating active efforts in biotech and the pharmaceutical industry to develop therapeutic CaMKII inhibitory drugs to treat heart failure and arrhythmias. We collaborate with several faculty in the Center for TB Research, Division of Infectious Diseases and the School of Public Health. We also work to better understand the mechanisms that form the striking connections between autoimmunity and cancer. Ongoing studies in our lab are focused on identifying the specific molecular targets modified by oxidative or ischemic stress and how they affect mitochondrial and whole heart function. Johns Hopkins Department of Physical Medicine and Rehabilitation in collaboration with the Applied Physics Laboratory of Johns Hopkins University are proud to announce a great new opportunity for Spinal Cord Injury patients to participate in a Brain-Computer Interface Study. Participants are being followed for identification and characterization of cardiovascular disease events, including acute myocardial infarction and other forms of coronary heart disease (CHD), stroke, and congestive heart failure; for cardiovascular disease interventions; and for mortality. The goal of our research is to understand how eukaryotic cells polarize, divide, move, and vary their genomes to adapt to the changing environment. Research in the Janet Record Lab focuses on medical education and patient-centered care. Current clinical research projects in the lab examine patient symptoms and experiences in rheumatic diseases and inflammatory arthritis. Dr. Crews’ team focuses on health disparities in chronic kidney disease. Additionally, we develop novel approaches for measuring acceptability and accuracy of point-of-care and OTC-type assays in primary care settings with comparisons between trained and untrained users. sildenafi, Viagra®), on myocyte signaling cascades modulated by protein kinase G, and on the nitric oxide synthase dysregulation coupled with oxidant stress. • Cardiac pacemaker physiology and disease Research Areas: occupational geriatrics, aging, gerontology. Research Areas: Raynaud's phenomenon, cancer, scleroderma, drugs, cardiovascular diseases. However, research from several laboratories uncovered a third type of photoreceptor cell in the mammalian retina, called intrinsically photosensitive retinal ganglion cells (ipRGCs) that express their own photopigment called melanopsin. Enter a research interest, principal investigator or keyword Enter a research … The Grant Louie Lab studies spondyloarthritis, including ankylosing spondylitis and nonradiographic axial spondyloarthritis. Dr. Approximately 38 percent of the recruited participants are white, 28 percent African-American, 22 percent Hispanic, and 12 percent Asian, predominantly of Chinese descent. • Physiological differences between isolated hearts in ventricular fibrillation and pulseless electrical activity Moreover, proteomic techniques afford the systematic assessment of post-translational modifications that regulate the activity of proteins responsible for every aspect of heart function from electrical excitation to contraction and metabolism. We also are studying topics that include down regulation of humoral alloimmunity; variability in immunogenicity among different HLA antigens; the involvement of non-HLA-specific antibodies in transplantation; the role of AT1R antibodies in organ transplantation; and desensitization in haploidentical hematopoietic stem-cell transplantation. Research Areas: inflammatory bowel disease, Crohn’s disease, ulcerative colitis. view more, Research Areas: antiretroviral drugs, infectious disease, HIV protease inhibitors, HIV, drugs, accelerator mass spectrometry. In 2014, we began to shift our focus from Drosophila to an emerging field of mosquito sensory biology. Research Areas: diabetes mellitus, hormones, hyperlipidemia, male gonadal function, cardiovascular diseases, endocrinology. Under physiological conditions, CaMKII is important for excitation-contraction coupling and fight or flight increases in heart rate. The motivation for all of the work is to understand Research Areas: Alpha-1 antitrypsin deficiency, sarcoidosis, genomics. Research in the David Hager Lab focuses on critical care medicine. We specialize in Hymenoptera (insect sting) venom-specific IgE and IgG antibody measurements. More recently, we (PIs Balagopal and Thio) integrated scLCM with droplet digital PCR (ddPCR) to reveal the first observations of hepatitis B virus (HBV) infection at single cell resolution in the liver. Research in the Anastasia Seymour Lab focuses on ambulatory care, prevention and integrative medicine. The Peisong Gao Lab’s major focus is to understand the immunological and genetic regulation of allergic diseases. Research Areas: kidney transplants, nephrology, health disparities, pancreas transplants. Research Areas: Focal segmental glomerular sclerosis in the transplanted kidney, Recurrent glomerular diseases post kidney transplant, Incompatible kidney transplant. We have also been characterizing the CNS pathways regulating the cough reflex and interactions amongst various afferent nerve subtypes in regulating cough. Research Areas: epidemiology, biomarkers, kidney diseases, HIV. The goal of the Fluorescence Imaging Core is to provide state-of-art light microscopy technology to the members of the Hopkins Basic Research Digestive Disease Development Center and to the whole Hopkins scientific community. th changes in mRNA transcripts. Please understand that our phone lines must be … Read all COVID-19 Vaccine Information. Research Areas: transplants, viral hepatitis, liver diseases, plasma exchange. Classics Research Lab (CRL) Classics Research Lab (CRL) In spring 2019 the Classics Department at Johns Hopkins launched an exciting initiative for undergraduates: a research “laboratory” in which students can enroll for credit as they would any normal course. The lab is part of the Brady Urological Institute (Urology Department at the Johns Hopkins Medicine) and is located at the Johns Hopkins Bayview Medical Center. We are unable to accept phone calls to schedule COVID-19 vaccinations at this time. In addition, the DACI Laboratory performs hypersensitivity pneumonitis precipitin panels, serum cotinine, and environmental mold measurements. The Allan Gelber Lab conducts research on the clinical epidemiology of rheumatic disorders. The curriculum teaches residents to use hand-carried ultrasound for imaging the inferior vena cava to assess volume status. Our studies include clinical trials on the effectiveness of rituximab versus cyclosporine in treating idiopathic membranous nephropathy and a multinational study of belimumab with azathioprine for maintaining remission of granulomatosis with polyangiitis and microscopic polyangiitis. Past projects include a nine-year longitudinal observation study of HIV-infected women in Baltimore. © The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. Research in the Jerry Spivak Lab focuses on chronic myeloproliferative disorders, particularly their molecular mechanisms and methods for distinguishing them diagnostically and interventionally. In addition, we are conducting several specific studies that examine the relationship between the bronchial vasculature and the influx of inflammatory cells to a patientÕs airways. Research in the lab has led to several groundbreaking genomic, epigenomic and bioinformatic studies of esophageal and colonic neoplasms, shifting the gastrointestinal research paradaigm toward genome-wide approaches. 89. Participants were recruited from six field centers across the United States, including Johns Hopkins University. The Lotan Laboratory. 855 North Wolfe Street | Rangos 287 | Baltimore, MD 21205 | 410-502-9193 Research in the Andrea Cox Lab explores the immune response in chronic viral infections, with a focus on HIV and the hepatitis C virus (HCV). Research Areas: anti-infective drugs, antiretroviral therapies, tuberculosis and HIV treatments, HIV, lung disease, pharmacology, tuberculosis. Dr. Steven M. Frank is a professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. © The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. When West left Bell Labs in 2001, he was attracted to Johns Hopkins by its collaborative research culture, which encouraged multidisciplinary approaches to solving problems. Fourth, host genetic determinants of spontaneous HBV recovery and HCV clearance. You can also consult departmental web pages and other online information. The Johns Hopkins Neuroscience Department site lists many of the neuroscience-related researchers on all Hopkins campuses. The Feinberg Laboratory studies the epigenetic basis of normal development and disease, including cancer, aging and neuropsychiatric illness. The clinical translation of research findings is an important focus for us. Research Areas: neurobiology, substance abuse, stress, hormones, physiogenetics, neuropsychoendocrinology, alcoholism. Dr. Grams received the 2019 Frederick Brancati Mentoring Award. Patient Care Options | Visitor Guidelines | Coronavirus Information | Self-Checker | Get Email Alerts. Research Home ... Find a Research Lab. In addition, we have studied the ways in which recent advances in communication research are impacting childhood obesity rates. We carry out electrophysiological and anatomical studies in isolated tissues and reflex studies in animal models. Dong I. Lee (Research Associate) Asst. Research Areas: gastrointestinal system, respiratory system, immunology, allergies, nociceptors, inflammation, pain, nervous system. Most recently, we have studied type 1 interferon responses to HIV-1 using RNA sequencing (RNAseq). Research Areas: gastroenterology, cancer, inflammation, molecular biology. By understanding the links between Ca2+, electrical excitability and energy production, we hope to understand the cellular basis of cardiac arrhythmias, ischemia-reperfusion injury, and sudden death. Moreover, proteomic techniques afford the systematic assessment of post-translational modifications that regulate the activity of proteins responsible for every aspect of heart function from electrical excitation to contraction and metabolism. We recently examined the relationship between violence against women and HIV-related risk factors in women living in the United States. Efforts at the laboratory, funded by grants from the National Institutes of Health, are highly collaborative and involve undergraduate assistants, graduate students, postdoctoral fellows and faculty. Johns Hopkins researchers have pioneered the creation of adeno-associated virus (AAV) gene therapy vectors and their introduction into clinical trials. This has included the investigation of the genetic basis of familial colorectal cancer and the use of genetic testing in the hereditary forms of colorectal cancer. We focus on the fate of autoantigens in target cells during various circumstances, such as viral infection, relevant immune effector pathways and exposure to ultraviolet radiation. We also conduct cohort studies assessing HIV, inflammation and nutrition in international settings; TB in pregnancy; and risk factors for TB in India (CTRIUMPH). Research Areas: evolutionary genomics, sequence analysis, genomics, genome annotation, genomic technologies, cleft lip and palate. Implementation of alternative advanced modalities has the potential to improve complex ablation procedures by guiding catheter placement, visualizing abnormal scar tissue, reducing procedural time devoted to mapping, and eliminating patient and operator exposure to radiation. Research Areas: medical education, patient-centered health care, imaging, internal medicine, inferior vena cava. Research Areas: HIV, hepatitis C, liver diseases. The Cardiology Bioengineering Laboratory, located in the Johns Hopkins Hospital, focuses on the applications of advanced imaging techniques for arrhythmia management. Ongoing research in the laboratories of Dr. William Guggino and Dr. Liudmila Cebotaru is aimed at unraveling the barriers to effective gene therapy and refining new vectors. We’re also interested in infectious diseases, particularly infection control, and the education of resident and medical students. Research Areas: pulmonary medicine, sarcoidosis, granulomatous inflammation, pulmonary fibrosis. Research Areas: autoantibodies, Sjogren's syndrome, autoimmune rheumatic diseases, observational data. • Molecular physiology of CaMKII Work in the Sophie Lanzkron Lab is focused on understanding the barriers to care for adults with sickle cell disease. All rights reserved. The majority of our research explores the various factors that improve a patient’s outcome during a cardiac arrest episode that takes place outside of a hospital. Researchers in the Ami Shah Lab study scleroderma and Raynaud’s phenomenon. Susan Carlson, Ph.D., is the AJ Rice Professor of Nutrition in the KU Department of Dietetics and Nutrition at KU Medical Center. Research in the Alan Scott Lab involves several important areas of genomics. Our research has shown that despite the approval of hydroxyurea treatment predicted to decrease hospitalizations for sickle cell disease patients' the cost of care has increased significantly in recent years. Research interests in the David Feller-Kopman Lab include improving the multidisciplinary treatment of patients with complex airway disease, investigating the physiology and pathophysiology of non-malignant central airway obstruction and pleural disease, and developing novel methods to teach procedural skills. Research Areas: pluripotent stem cells, stem cells, molecular genetics, stem cell biology, gene therapy. Research interests in the Eun Ji Shin Lab include clinical research on obesity and the effect on GI neoplasia/malignancy. Recently, we developed an EHR-based genetic testing knowledge base to be integrated into the genetic testing ontology (GTO) and identified potential barriers to pharmacogenomics clinical decision support (CDS) implementation. Research Areas: poverty, chronic kidney disease, health disparities. We have conducted population studies to examine the distribution of human leukocyte antigen (HLA) alleles and haplotypes, minor histocompatibility antigens, killer-cell immunoglobulin-like receptors (KIRs) and cytokine alleles in a number of racial and ethnic groups. Research Areas: cystic fibrosis, pulmonary arteriovenous malformations, HIV, lung disease, lung transplant. Research in the Marian Kollarik Lab focuses on specific phenotype of visceral sensory nerves, termed nociceptive, that detect stimuli associated with impeding or actual tissue damage. s for studying how defective function of one component of the cell can lead to catastrophic effects on whole cell and whole organ function. Investigators in the Robert Brodsky Lab study normal and abnormal hematopoiesis, particularly mutations of the phosphatidylinositol glycan anchor biosynthesis class A (PIG-A) gene in aplastic anemia. view more, The Cardiology Bioengineering Laboratory, located in the Johns Hopkins Hospital, focuses on the applications of advanced imaging techniques for arrhythmia management. The resulting biorepository will allow unprecedented opportunity to study chemotherapy in children. Our work aims to understand how the organization environment of health care affects the type and quality of care that patients receive. This website is a resource to help advance the understanding of the virus, inform the public, and brief policymakers in order to guide a response, improve care, and save lives. We focus on stiffness in rheumatoid arthritis and patient-reported outcomes. Our recent research has also explored recipient and donor variables in the success or failure of lung transplants, and ways in which national healthcare delivery systems impact lung transplant outcomes for CF patients. Asst. When this changes, we will update this web site. -dependent protein kinase II (CaMKII). We capture data and biological specimens from patients with spondyloarthritis. Importantly, inflammation profoundly alters properties of nociceptive nerves per se, leading in general to exaggerated nociceptive responsiveness. Research Areas: HIV, insulin, cardiovascular diseases, cholesterol. However, during antiviral therapy, HBV infection is diminished while viral transcription is markedly attenuated. Research Areas: pulmonary arterial hypertension, molecular genetics, cardiopulmonary diseases, asthma, epigenetics, complex lung disease, allergies, genomics, COPD, atopic dermatitis. We also study clinical markers and contributing factors in the progression of kidney disease, and the association between kidney disease and h. Our research group is participating in a multicenter consortium serving as a clinical core site to study the pathogenesis of HIV-associated kidney disease by providing well-characterized clinical specimens and corresponding clinical and laboratory data. Research Specialist at Brigham and Women's Hospital. Our team collaborates on a study to investigate the exon and genome sequence variants that determine phenotype, with a specific focus on the genetic bases of cleft lip and palate. The Johns Hopkins University Applied Physics Laboratory We solve complex research, engineering, and analytical problems that present critical challenges to our nation. (2004-2019) 90. associate professor of medicine at Johns Hopkins University. Research Areas: autoantigens, autoimmune diseases, cytotoxic granule proteases, peptidylarginine deiminase enzymes, rheumatoid arthritis. le pathways or biomarkers that underlie the development of chronic kidney disease using multi-omic approaches. Le Cancer Metabolism Research Lab. Pei-Shan Wang, PhD. Research Areas: gut bacteria, nutrition, obesity, weight loss. Research Areas: epidemiology, sickle cell diseases, kidney diseases, venous thromboembolism, hemoglobin disorders, genetic counseling. We are identifying the non-HLA targets of endothelial cell reactive antibodies to allow for improved detection of these antibodies and to decipher their role in allograft injury. Work in the Anika Alvanzo Lab focuses on screening and interventions for at-risk substance use, and race, ethnicity and sex differences in substance use disorders.

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